While driving to Las Vegas for the bachelor party of her sister Melissa and her fiancé Bobby, Kayla stops the car in the gas station to meet her date, Nik, a guy she met on the internet. Nik convinces her to take a secondary road under the protest of Bobby but the car breaks down. They find a house in the middle of nowhere and decide to take the car parked in the house's garage to the next city, and return with a rented car to pay for the damages provoked by Nik; Melissa leaves her cell number. However, they discover that the owner of the place is the sadistic truck driver Rusty Nail and they have to pay a high price for what they did.
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College student Lewis decides to drive across the country to see Venna, a friend who doesn't know that Lewis is interested in her romantically. Unfortunately for his plans, Lewis gets saddled with his raucous-spirited older brother, Fuller, whose on-the-road pranks get the brothers and Venna sucked into a nightmare when a psychotic truckdriver takes offense.
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Rusty Nail is back on the road again looking to punish injustice at every turn - and this time it's with a group of hotheaded street racers on their way to the Road Rally 1000. As they drive through a desolate shortcut on the way to the race, an encounter with Rusty turns sour and soon he is tracking, teasing and torturing them until the end of the road.
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